FOXO4-DRI

A D-retro-inverso peptide examined in laboratory senescence research models.

FOXO4-DRI is a synthetic D-retro-inverso peptide designed around the interaction interface between the FOXO4 transcription factor and the tumor-suppressor protein p53. In the published literature it appears predominantly in cellular-senescence and senolytic research models. Describing it as "studied in" these areas indicates where scientific attention has been directed, not a claim of any result. This page is background about the molecule as a research material and is not medical guidance or intended for human use.

Classification and structure

FOXO4-DRI is classified as a synthetic D-retro-inverso peptide. It is built from D-amino acids in reversed sequence, an approach used in research to increase peptide stability while preserving side-chain topology. Its sequence targets the FOXO4-p53 interaction that has been the subject of senescence research, and it is handled in the laboratory as a defined peptide research compound.

Areas of research

FOXO4-DRI appears across a few defined areas of the research literature.

• Cellular senescence — Investigated in research examining senescent-cell biology in vitro.
• Senolytic research models — Appears in the literature on FOXO4-p53 interaction and senescent-cell research.
• Aging-biology models — Has been the subject of research examining senescence markers in model systems.

As always in this library, describing a compound as “studied in” an area is a statement about where scientific attention has gone — not a claim that it produces any result in humans or animals.

Handling and verification

Store lyophilized material cold and protected from light and moisture, in line with standard peptide-handling practice. Every in-stock lot ships with a verifiable third-party certificate of analysis (COA) confirming identity and purity.